Gen-Tropin AQx 191a Profile:
Human growth hormone (GH) is a protein hormone consisting of several isoforms. It is encoded by a gene cluster located on chromosome 17q, made up of 2GH genes: GH1 and GH2; GH1 transcripts yield (through alternative mRNA splicing) two protein products: the pituitary 22KDa GH form and 20KDa GH.1 Since the 22KDa GH-encoding GH1 gene is expressed in the pituitary, secretion of its protein products is pulsatile under control from the hypothalamus.
There are minor differences in metabolic bioactivity among the GH isoforms, depending on species and assay system used; however GH isoforms cross-react in most immunoassays, and assays specific for 22KDa GH, 20KDa GH and GH-V (GH2 encoded isoform) have been developed.1 The metabolic clearance of 22KDa GH is faster compared to that of 20KDa isoform.
GH plays a crucial role in maintaining the homogeneity of tissues and organs during the normal development or after an injury. Its effects on growth do not take place during the foetal period or during the early infancy but are mediated by IGF-I (Insulin-like Growth Factor I) during childhood and puberty. IGF-I transcription is thereafter dependent on an adequate GH secretion, but in many tissues, occurs independent of GH.
The great diversity of actions of GH indicate that the hormone plays many different roles by activating a high number of proteins involved in cell signalling and displaying different mechanisms of action.
Some studies suggest that, rather than a hormone, GH is a pro-hormone that may be proteolytically cleaved yielding different and shorter GH derivatives with tissue-specific properties. Moreover, GH may activate the proliferation of tissue-specific stem cells that play an important role in tissue repair after an injury.
Therefore GH may be considered safe if administered in the appropriate doses and frequency. A classical GH-dependent adverse effect such as hyperglycaemia may not be of great importance if GH is administered before physical exercise. What is more, recently, there have been reports that GH is able to induce the rescue of pancreatic β-cell function in streptozotocin-treated mice and, therefore, has a potential in the treatment of type 1 diabetes.
Gen-Tropin AQx is a recombinant human GH product [Somatropin (rDNA origin)], manufactured by Bio-Gen Pharma, China. Gen-Tropin AQx is produced using recombinant DNA technology via bacterial (E. coli) expression system, and is identical to the endogenous HGH. Each cartridge contains 10mg (30IU) of rHGH in a sterile stable liquid formulation.
22 kDa protein containing 191 amino acid residues.
FPTI PLSRLFDNAM LRAHRLHQLA FDTYQEFEEA YIPKEQKYSF LQNPQTSLCF SESIPTPSNR EETQQKSNLE LLRISLLLIQ SWLEPVQFLR SVFANSLVYG ASDSNVYDLL KDLEEGIQTL MGRLEDGSPR TGQIFKQTYS KFDTNSHNDDALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF
HGH, Human Growth Hormone, Somatropin, Somatotropin.
Sterile Filtered clear liquid formulation.
The amino acid sequence and tertiary structure of the Gen-Tropin AQx somatropin (HGH) is identical to naturally produced HGH. Therefore, Gen-Tropin AQx HGH has an affinity to HGH receptors.
>95% (SDS-PAGE analyzed).
Liquid formulation no need for bacteriostatic water.
Store liquid protein formulation at 4 °C. The liquid formulated protein remains stable until the expiry date when stored at 4 °C.
Product is prepared for LABORATORY RESEARCH USE ONLY. The product may not be used for other purposes.
- Baumann, G. Growth hormone isoforms. Growth Horm IGF Res. 2009 Aug; 19(4): 333–340.
- Baumann, G., Stolar, M.W., Buchanan, T.A. Slow metabolic clearance rate of the 20,000-dalton variant of human growth hormone: implications for biological activity. Endocrinology. 1985;117:1309–1313.
- Devesa J, Almengló C, Devesa P. Multiple Effects of Growth Hormone in the Body: Is it Really the Hormone for Growth? Clinical Medicine Insights Endocrinology and Diabetes. 2016;9:47-71.
- Ray BN, Kweon HK, Argetsinger LS, Fingar DC, Andrews PC, Carter-Su C. Research resource: identification of novel growth hormone-regulated phosphorylation sites by quantitative phosphoproteomics. Mol Endocrinol. 2012;26:1056–1073
- Carter-Su C, Schwartz J, Argetsinger LS. Growth hormone signaling pathways. Growth Horm IGF Res. 2016;28:11–15.
- Scheinman EJ, Damouni R, Caspi A, Shen-Orr Z, Tiosano D, LeRoith D. The beneficial effect of growth hormone treatment on islet mass in streptozotocin-treated mice. Diabetes Metab Res